The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway.

The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway.

Stimulator of interferon genes (STING) is critical for cytosolic DNA-triggered innate immunity. STING is modified by several types of polyubiquitin chains. Here, we report that the deubiquitinase CYLD sustains STING signaling by stabilizing the STING protein. CYLD deficiency promoted the K48-linked...

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Bibliographic Details
Main Authors: Lele Zhang, Ning Wei, Ye Cui, Ze Hong, Xing Liu, Qiang Wang, Senlin Li, Heng Liu, Huansha Yu, Yanni Cai, Quanyi Wang, Juanjuan Zhu, Wei Meng, Zhengjun Chen, Chen Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6235404?pdf=render

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http://europepmc.org/articles/PMC6235404?pdf=render

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