Interleukin-32θ inhibits tumor-promoting effects of macrophage-secreted CCL18 in breast cancer

Interleukin-32θ inhibits tumor-promoting effects of macrophage-secreted CCL18 in breast cancer

Abstract Background Tumor-associated macrophages can promote breast cancer metastasis by secreting cytokines and growth factors. Interleukin (IL)-32θ, a newly identified IL-32 isoform, was previously shown to down-regulate various proinflammatory factors of macrophages. Here, we report the presence...

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Bibliographic Details
Main Authors: Thu-Huyen Pham, Yesol Bak, Taeho Kwon, Sae-Bom Kwon, Jae-Wook Oh, Jong-Hyung Park, Yang-Kyu Choi, Jin Tae Hong, Do-Young Yoon
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cell Communication and Signaling
Subjects:
IL-32θ
Macrophage
Breast cancer metastasis
CCL18
PKCδ
STAT3
Online Access:http://link.springer.com/article/10.1186/s12964-019-0374-y

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http://link.springer.com/article/10.1186/s12964-019-0374-y

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