Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress

Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress

Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder caused by dysfunction and degeneration of motor neurons. Multiple disease-causing mutations, including in the genes for SOD1 and TDP-43, have been identified in ALS. Astrocytes expressing mutant SOD1 are strongly implicated in the pat...

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Bibliographic Details
Main Authors: Fabiola eRojas, Nicole eCortes, Sebastian eAbarzua, Agnieszka eDyrda, Brigitte A.J. Van Zundert
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
motor neuron
degeneration
ALS
non-cell-autonomous
ROS/RNS
anti-oxidants.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00024/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00024/full

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