Functional hyperemia drives fluid exchange in the paravascular space

Abstract The brain lacks a conventional lymphatic system to remove metabolic waste. It has been proposed that directional fluid movement through the arteriolar paravascular space (PVS) promotes metabolite clearance. We performed simulations to examine if arteriolar pulsations and dilations can drive...

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Bibliographic Details
Main Authors: Ravi Teja Kedarasetti, Kevin L. Turner, Christina Echagarruga, Bruce J. Gluckman, Patrick J. Drew, Francesco Costanzo
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Fluids and Barriers of the CNS
Online Access:http://link.springer.com/article/10.1186/s12987-020-00214-3