Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment.

Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment.

Sand fly saliva plays a crucial role in establishing Leishmania infection. We identified adenosine (ADO) and adenosine monophosphate (AMP) as active pharmacologic compounds present in Phlebotomus papatasi saliva that inhibit dendritic cell (DC) functions through a PGE2/IL 10-dependent mechanism.Here...

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Bibliographic Details
Main Authors: Vanessa Carregaro, José M Ribeiro, Jesus G Valenzuela, Djalma L Souza-Júnior, Diego L Costa, Carlo J F Oliveira, Laís A Sacramento, Manuela S L Nascimento, Cristiane M Milanezi, Fernando Q Cunha, João S Silva
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4388340?pdf=render

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http://europepmc.org/articles/PMC4388340?pdf=render

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