Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation

Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation

Summary: Recent studies have revealed an essential role for embryonic cortical development in the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD). However, the genetic basis and underlying mechanisms remain unclear. Here, we generate mutant human embryonic s...

Full description

Bibliographic Details
Main Authors:	Ke Zhang, Fang Yu, Jian Zhu, Sue Han, Jiehui Chen, Xuanyuan Wu, Yingying Chen, Tingyu Shen, Jiaoyang Liao, Wenke Guo, Xianfa Yang, Ran Wang, Yun Qian, Jiaxin Yang, Leping Cheng, Yun Zhao, Chi-Chung Hui, Jinsong Li, Guangdun Peng, Shuijin He, Naihe Jing, Ke Tang
Format:	Article
Language:	English
Published:	Elsevier 2020-04-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124720304204

Similar Items

Effects of NR1 splicing on NR1/NR3B-type excitatory glycine receptors
by: Orth Angela, et al.
Published: (2009-04-01)

Excitatory-inhibitory imbalance in Alzheimer's disease and therapeutic significance
by: Eva Vico Varela, et al.
Published: (2019-07-01)

Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models
by: Cheryl L Gatto, et al.
Published: (2010-06-01)

Imbalance of laminar-specific excitatory and inhibitory circuits of the orbitofrontal cortex in autism
by: Xuefeng Liu, et al.
Published: (2020-10-01)

MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders
by: Adam J Harrington, et al.
Published: (2016-10-01)

Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease
by: Megha Sah, et al.
Published: (2020-04-01)

Electrophysiological Marker of a Potential Excitatory/Inhibitory Imbalance in Children with Autism Spectrum Disorder
by: Shuffrey, Lauren Christine
Published: (2017)

Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells
by: Chang Liu, et al.
Published: (2018-07-01)

NR2 subunits and NMDA receptors on lamina II inhibitory and excitatory interneurons of the mouse dorsal horn
by: MacDermott Amy B, et al.
Published: (2010-05-01)

Prenatal sevoflurane exposure causes neuronal excitatory/inhibitory imbalance in the prefrontal cortex and neurofunctional abnormality in rats
by: Tianyun Zhao, et al.
Published: (2020-12-01)

Brain MR Spectroscopy in Autism Spectrum Disorder- the GABA excitatory/inhibitory imbalance theory revisited
by: Maiken Kirkegaard Brix, et al.
Published: (2015-06-01)

The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders
by: Cheen Euong Ang, et al.
Published: (2019-01-01)

Shikonin Inhibits Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts via lncRNA-NR024118
by: Ke-ya Yang, et al.
Published: (2015-01-01)

Inhibitory-excitatory imbalance in hippocampal subfield cornu ammonis 2 circuitry in a mouse model of temporal lobe epilepsy
by: Whitebirch, Alexander Craig
Published: (2021)

Exposure to Prenatal Stress Is Associated With an Excitatory/Inhibitory Imbalance in Rat Prefrontal Cortex and Amygdala and an Increased Risk for Emotional Dysregulation
by: Francesca Marchisella, et al.
Published: (2021-06-01)

Author Correction: Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII
by: Su Feng, et al.
Published: (2018-05-01)

Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII
by: Su Feng, et al.
Published: (2017-07-01)

Case Report: A de novo CTNNB1 Nonsense Mutation Associated With Neurodevelopmental Disorder, Retinal Detachment, Polydactyly
by: Zhongling KE, et al.
Published: (2020-12-01)

The excitatory synaptic transmission of the nucleus of solitary tract was potentiated by chronic myocardial infarction in rats.
by: Jing Li, et al.
Published: (2015-01-01)

Endomorphin-2 Decreases Excitatory Synaptic Transmission in the Spinal Ventral Horn of the Rat
by: Zhen-Yu Wu, et al.
Published: (2017-08-01)

Neuroligin1 Contributes to Neuropathic Pain by Promoting Phosphorylation of Cofilin in Excitatory Neurons
by: Junlin Ouyang, et al.
Published: (2021-02-01)

Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors
by: Chen, Philip Eng-Chi
Published: (2000)

An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake
by: Jia Zhang, et al.
Published: (2020-12-01)

Genome-wide analysis of histone acetylation dynamics during mouse embryonic stem cell neural differentiation
by: Pingyu Liu, et al.
Published: (2015-09-01)

Genome-wide ChIP-seq and RNA-seq analyses of Pou3f1 during mouse pluripotent stem cell neural fate commitment
by: Lu Song, et al.
Published: (2015-09-01)

Neurodevelopmental Disorder
by: Dimitris Argiropoulos
Published: (2020-02-01)

Multiple effects of β-amyloid on single excitatory synaptic connections in the PFC
by: Yun eWang, et al.
Published: (2013-09-01)

The amygdala excitatory/inhibitory balance in a valproate-induced rat autism model.
by: Hui-Ching Lin, et al.
Published: (2013-01-01)

N.R.
Published: (2010-01-01)

The Viability of Security Markets under Order Imbalances
by: Lee Yun Chi, et al.
Published: (2001)

Day Trade, Order Imbalance and Stock Return
by: HUANG. YU YUN, et al.
Published: (2015)

Gβ5 is not essential for spatial distribution of excitatory synapses in mouse retinal ganglion cells
by: Sun, Chi-Yun, et al.
Published: (2015)

6′-Hydroxy Justicidin B Triggers a Critical Imbalance in Ca2+ Homeostasis and Mitochondrion-Dependent Cell Death in Human Leukemia K562 Cells
by: Jiaoyang Luo, et al.
Published: (2018-06-01)

Neurodevelopmental correlates in schizophrenia
by: Ivković Maja, et al.
Published: (2003-01-01)

Hyperbilirubinemia and Neurodevelopmental Outcome
by: J Gordon Millichap
Published: (1989-06-01)

Neurodevelopmental models of Schizophrenia
by: Wood, Graham
Published: (2008)

The neurodevelopmental hypothesis of schizophrenia
by: Bell, Rachel Ann
Published: (1999)

Neurodevelopment and Neurodevelopmental Disorder
Published: (2019)

Epilepsy and Neurodevelopmental Diseases
Published: (2020)

Neuromodulation of excitatory synaptogenesis in striatal development
by: Yevgenia Kozorovitskiy, et al.
Published: (2015-11-01)