Chemoresistance-Associated Silencing of miR-4454 Promotes Colorectal Cancer Aggression through the <i>GNL3L</i> and <i>NF-κB</i> Pathway

Chemoresistance-Associated Silencing of miR-4454 Promotes Colorectal Cancer Aggression through the <i>GNL3L</i> and <i>NF-κB</i> Pathway

Guanine nucleotide-binding protein-like-3-like (<i>GNL3L</i>) is a crucial regulator of <i>NF-κB</i> signaling that is aberrantly activated during diverse chemoresistance-associated cellular processes. However, the molecular mechanisms of <i>GNL3L</i> tumor initia...

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Bibliographic Details
Main Authors: Thetchinamoorthy Kannathasan, Wei-Wen Kuo, Ming-Cheng Chen, Vijaya Padma Viswanadha, Chia-Yao Shen, Chuan-Chou Tu, Yu-Lan Yeh, Mahalakshmi Bharath, Marthandam Asokan Shibu, Chih-Yang Huang
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
colorectal cancer (CRC)
irinotecan (CPT-11)
miR-4454
<i>GNL3L</i> (guanine nucleotide-binding protein-like-3-like)
Online Access:https://www.mdpi.com/2072-6694/12/5/1231

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