Testing whether the progression of Alzheimer’s disease changes with the year of publication, additional design, and geographical area: a modeling analysis of literature aggregate data

Testing whether the progression of Alzheimer’s disease changes with the year of publication, additional design, and geographical area: a modeling analysis of literature aggregate data

Abstract Background Our objectives were to develop a disease progression model for cognitive decline in Alzheimer’s disease (AD) and to determine whether disease progression of AD is related to the year of publication, add-on trial design, and geographical regions. Methods Placebo-controlled randomi...

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Bibliographic Details
Main Authors: Ningyuan Zhang, Xijun Zheng, Hongxia Liu, Qingshan Zheng, Lujin Li
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Disease progression model
Model-based meta-analysis
modeling and simulation
Online Access:http://link.springer.com/article/10.1186/s13195-020-00630-5

Internet

http://link.springer.com/article/10.1186/s13195-020-00630-5

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