Next generation sequencing to decipher concurrent loss of PMS2 and MSH6 in colorectal cancer

Next generation sequencing to decipher concurrent loss of PMS2 and MSH6 in colorectal cancer

Abstract Background Immunohistochemistry (IHQ) is commonly used for the detection of mismatch repair proteins deficiency (MMRD). One very infrequent abnormal pattern of MMR protein expression is the loss of PMS2 and MSH6, with intact expression of MLH1 and MSH2. Case presentation We review the frequ...

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Bibliographic Details
Main Authors: Esther Moreno, Juan M. Rosa-Rosa, Tamara Caniego-Casas, Ignacio Ruz-Caracuel, Cristian Perna, Carmen Guillén, José Palacios
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Diagnostic Pathology
Subjects:
Colorectal cancer
Mismatch repair deficiency
Lynch syndrome
NGS
Case report
Online Access:http://link.springer.com/article/10.1186/s13000-020-01001-2

Internet

http://link.springer.com/article/10.1186/s13000-020-01001-2

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