Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases

Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases

Abstract Under normal conditions, astrocytes perform a number of important physiological functions centered around neuronal support and synapse maintenance. In neurodegenerative diseases including Alzheimer’s, Parkinson’s and prion diseases, astrocytes acquire reactive phenotypes, which are sustaine...

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Bibliographic Details
Main Authors: Rajesh Kushwaha, Anshuman Sinha, Natallia Makarava, Kara Molesworth, Ilia V. Baskakov
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Acta Neuropathologica Communications
Subjects:
Prions
Prion diseases
Astrocytes
Microglia
Neuroinflammation
Synaptic toxicity
Online Access:https://doi.org/10.1186/s40478-021-01123-8

Internet

https://doi.org/10.1186/s40478-021-01123-8

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