Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya

Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya

Abstract Background Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic susceptibility factors in immune regulatory genes offers an important tool for...

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Bibliographic Details
Main Authors: Elly O. Munde, Evans Raballah, Winnie A. Okeyo, John M. Ong’echa, Douglas J. Perkins, Collins Ouma
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Infectious Diseases
Subjects:
Il-23R
Exon
Genotypes
Haplotypes
Online Access:http://link.springer.com/article/10.1186/s12879-017-2404-y

Internet

http://link.springer.com/article/10.1186/s12879-017-2404-y

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