Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: <it>FLT3 ITD sustains high levels of DUSP6 expression</it>

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: <it>FLT3 ITD sustains high levels of DUSP6 expression</it>

<p>Abstract</p> <p>Protein-tyrosine phosphatases (PTPs) are important regulators of cellular signaling and changes in PTP activity can contribute to cell transformation. Little is known about the role of PTPs in Acute Myeloid Leukemia (AML). The aim of this study was therefore to e...

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Bibliographic Details
Main Authors: Arora Deepika, Köthe Susanne, van den Eijnden Monique, van Huijsduijnen Rob, Heidel Florian, Fischer Thomas, Scholl Sebastian, Tölle Benjamin, Böhmer Sylvia-Annette, Lennartsson Johan, Isken Fabienne, Müller-Tidow Carsten, Böhmer Frank-D
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Cell Communication and Signaling
Subjects:
Acute myeloid leukemia
Protein-tyrosine phosphatases
Dual-specificity phosphatases (DUSP)
mRNA expression
Fms-like tyrosine kinase (FLT3) with internal tandem duplication (ITD)
DUSP6
ERK signaling
Online Access:http://www.biosignaling.com/content/10/1/19

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http://www.biosignaling.com/content/10/1/19

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