Proteome-wide screening reveals immunodominance in the CD8 T cell response against classical swine fever virus with antigen-specificity dependent on MHC class I haplotype expression.

Proteome-wide screening reveals immunodominance in the CD8 T cell response against classical swine fever virus with antigen-specificity dependent on MHC class I haplotype expression.

Vaccination with live attenuated classical swine fever virus (CSFV) vaccines induces a rapid onset of protection which has been associated with virus-specific CD8 T cell IFN-γ responses. In this study, we assessed the specificity of this response, by screening a peptide library spanning the CSFV C-s...

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Bibliographic Details
Main Authors: Giulia Franzoni, Nitin V Kurkure, Sabine E Essler, Miriam Pedrera, Helen E Everett, Kikki B Bodman-Smith, Helen R Crooke, Simon P Graham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3871537?pdf=render

Internet

http://europepmc.org/articles/PMC3871537?pdf=render

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