Chromatin remodeling pathways in smooth muscle cell differentiation, and evidence for an integral role for p300.

Phenotypic alteration of vascular smooth muscle cells (SMC) in response to injury or inflammation is an essential component of vascular disease. Evidence suggests that this process is dependent on epigenetic regulatory processes. P300, a histone acetyltransferase (HAT), activates crucial muscle-spec...

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Bibliographic Details
Main Authors: Joshua M Spin, Thomas Quertermous, Philip S Tsao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3001469?pdf=render