Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease

Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease

Abstract Background Nonalcoholic fatty liver disease (NAFLD) can lead to chronic liver diseases associated with mitochondrial damages. However, the exact mechanisms involved in the etiology of the disease are not clear. Methods To gain new insights, the changes affecting sirtuin 1 (SIRT-1) during li...

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Bibliographic Details
Main Authors: Yan Jiang, Duankai Chen, Qiming Gong, Qunqing Xu, Dong Pan, Feiyan Lu, Qianli Tang
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Lipids in Health and Disease
Subjects:
Sirtuin 1
Peroxisome proliferator-activated receptor-gamma coactivator -1a
Mitochondrial physiology
Mitochondrial autophagy
Mitochondrial dysfunction; Lipid autophagy
Nonalcoholic fatty liver disease
Online Access:https://doi.org/10.1186/s12944-021-01461-5

Internet

https://doi.org/10.1186/s12944-021-01461-5

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