From Powerhouse to Perpetrator—Mitochondria in Health and Disease

From Powerhouse to Perpetrator—Mitochondria in Health and Disease

In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect meta...

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Bibliographic Details
Main Authors: Nima B. Fakouri, Thomas Lau Hansen, Claus Desler, Sharath Anugula, Lene Juel Rasmussen
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Biology
Subjects:
mitochondria
cancer
nucleotide metabolism
DNA damage
NAD<sup>+</sup>
Online Access:https://www.mdpi.com/2079-7737/8/2/35

Internet

https://www.mdpi.com/2079-7737/8/2/35

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