Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

S-Palmitoylation is the only reversible post-translational lipid modification. Knowledge about the DHHC palmitoyltransferase family is still limited. Here we show that human ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16,...

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Bibliographic Details
Main Authors: Laurence Abrami, Tiziano Dallavilla, Patrick A Sandoz, Mustafa Demir, Béatrice Kunz, Georgios Savoglidis, Vassily Hatzimanikatis, F Gisou van der Goot
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
palmitoylation
ERAD
DHHC
turnover
Acyl protein thioesterase
endoplasmic reticulum
Online Access:https://elifesciences.org/articles/27826

Internet

https://elifesciences.org/articles/27826

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