PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease

PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease

Background: Gangliosides were found to be associated with Alzheimer's disease (AD). Here we addressed a potential function of γ-secretase (presenilin) dependent cleavage of the amyloid-precursor-protein (APP) in the regulation of ganglioside de novo synthesis. Methods: To identify a po...

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Bibliographic Details
Main Authors: Marcus O.W. Grimm, Benjamin Hundsdörfer, Sven Grösgen, Janine Mett, Valerie C. Zimmer, Christoph P. Stahlmann, Viola J. Haupenthal, Tatjana L. Rothhaar, Johannes Lehmann, Andreas Pätzold, Eva G. Zinser, Heikki Tanila, Jie Shen, Ulrike Müller, Heike S. Grimm, Tobias Hartmann
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Alzheimer’s disease
Presenilin
Amyloid precursor protein
Gangliosides
Glucosylceramide synthase
Online Access:http://www.karger.com/Article/FullText/362987

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http://www.karger.com/Article/FullText/362987

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