Nonsense‐mediated decay factor SMG7 sensitizes cells to TNFα‐induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1

Nonsense‐mediated decay factor SMG7 sensitizes cells to TNFα‐induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1

Nonsense‐mediated decay (NMD) proteins are responsible for the surveillance and degradation of aberrant RNAs. Suppressor with morphogenetic effect on genitalia 7 (SMG7) is an NMD complex protein and a regulator of tumor necrosis factor (TNF)‐induced extrinsic apoptosis; however, this unique function...

Full description

Bibliographic Details
Main Authors: Limeng Yang, Vanessa A. N. Kraft, Susanne Pfeiffer, Juliane Merl‐Pham, Xuanwen Bao, Yu An, Stefanie M. Hauck, Joel A. Schick
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Molecular Oncology
Subjects:
apoptosis
cancer
CYLD
lncRNA
nonsense‐mediated decay
Smg7
Online Access:https://doi.org/10.1002/1878-0261.12754

Internet

https://doi.org/10.1002/1878-0261.12754

Similar Items