Reaction Mechanism and Substrate Specificity of Iso-orotate Decarboxylase: A Combined Theoretical and Experimental Study

Reaction Mechanism and Substrate Specificity of Iso-orotate Decarboxylase: A Combined Theoretical and Experimental Study

The C-C bond cleavage catalyzed by metal-dependent iso-orotate decarboxylase (IDCase) from the thymidine salvage pathway is of interest for the elucidation of a (hypothetical) DNA demethylation pathway. IDCase appears also as a promising candidate for the synthetic regioselective carboxylation of N-...

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Bibliographic Details
Main Authors: Xiang Sheng, Katharina Plasch, Stefan E. Payer, Claudia Ertl, Gerhard Hofer, Walter Keller, Simone Braeuer, Walter Goessler, Silvia M. Glueck, Fahmi Himo, Kurt Faber
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Chemistry
Subjects:
computational chemistry
biocatalysis
iso-orotate decarboxylase
reaction mechanism
substrate specificity
metal identity
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00608/full

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https://www.frontiersin.org/article/10.3389/fchem.2018.00608/full

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