Delayed Onset of Symptoms and Atovaquone-Proguanil Chemoprophylaxis Breakthrough by Plasmodium malariae in the Absence of Mutation at Codon 268 of pmcytb.

Plasmodium malariae is widely distributed across the tropics, causing symptomatic malaria in humans with a 72-hour fever periodicity, and may present after latency periods lasting up to many decades. Delayed occurrence of symptoms is observed in humans using chemoprophylaxis, or patients having rece...

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Bibliographic Details
Main Authors: Beatrix Huei-Yi Teo, Paul Lansdell, Valerie Smith, Marie Blaze, Debbie Nolder, Khalid B Beshir, Peter L Chiodini, Jun Cao, Anna Färnert, Colin J Sutherland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4618945?pdf=render