Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains

Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains

Hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels represent the molecular substrate of the hyperpolarization-activated inward current (Ih). Although these channels act as pacemakers for the generation of rhythmic activity in the thalamocortical network during sleep and epilep...

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Bibliographic Details
Main Authors: Tatyana Kanyshkova, Patrick Meuth, Pawan Bista, Zhiqiang Liu, Petra Ehling, Luigi Caputi, Michael Doengi, Dane M. Chetkovich, Hans-Christian Pape, Thomas Budde
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Subjects:
h-current
Thalamocortical relay neurons
Absence epilepsy
Thalamic dysfunction
Computer modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003020

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http://www.sciencedirect.com/science/article/pii/S0969996111003020

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