Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

Abstract Background Skeletal muscle is one of the primary tissues involved in the development of type 2 diabetes (T2D). The close association between obesity and T2D makes it difficult to isolate specific effects attributed to the disease alone. Therefore, here we set out to identify and characteriz...

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Bibliographic Details
Main Authors: Leif Väremo, Tora Ida Henriksen, Camilla Scheele, Christa Broholm, Maria Pedersen, Mathias Uhlén, Bente Klarlund Pedersen, Jens Nielsen
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Genome Medicine
Subjects:
Type 2 diabetes
Obesity
Skeletal myocytes
RNA-seq
Gene expression
Gene-set analysis
Online Access:http://link.springer.com/article/10.1186/s13073-017-0432-2

Internet

http://link.springer.com/article/10.1186/s13073-017-0432-2

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