Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome

Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome

Background: Impaired alveolar macrophage (AM) efferocytosis may contribute to acute respiratory distress syndrome (ARDS) pathogenesis; however, studies are limited by the difficulty in obtaining primary AMs from patients with ARDS. Our objective was to determine whether an in vitro model of ARDS can...

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Bibliographic Details
Main Authors: Rahul Y. Mahida, Aaron Scott, Dhruv Parekh, Sebastian T. Lugg, Kylie B. R. Belchamber, Rowan S. Hardy, Michael A. Matthay, Babu Naidu, David R. Thickett
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Medicine
Subjects:
ARDS (acute respiratory disease syndrome)
alveolar macrophage (AM)
efferocytosis
BAL (bronchoalveolar lavage)
Rac1
Rho-associated kinase (ROCK) inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.737859/full

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https://www.frontiersin.org/articles/10.3389/fmed.2021.737859/full

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