HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity

HDAC Inhibition Suppresses Cardiac Hypertrophy and Fibrosis in DOCA-Salt Hypertensive Rats via Regulation of HDAC6/HDAC8 Enzyme Activity

Background: Inhibition of histone deacetylase (HDAC) was reported to suppress cardiac hypertrophy and fibrosis in various hypertrophic animal models. However, the HDAC expression profile and HDAC enzyme activity have not yet been investigated in DOCA-salt hypertensive rats. Methods: Unilaterally nep...

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Bibliographic Details
Main Authors: Hae Jin Kee, Eun Hui Bae, Sangha Park, Ko Eun Lee, Sang Heon Suh, Soo Wan Kim, Myung Ho Jeong
Format: Article
Language:English
Published: Karger Publishers 2013-07-01
Series:Kidney & Blood Pressure Research
Subjects:
GATA6
HDAC enzyme activity
Cardiac hypertrophy
DOCA-salt hypertensive rats
Histone deacetylase inhibitor
Online Access:http://www.karger.com/Article/FullText/350148

Internet

http://www.karger.com/Article/FullText/350148

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