Synthetic Approaches to Mono- and Bicyclic Perortho-Esters with a Central 1,2,4-Trioxane Ring as the Privileged Lead Structure in Antimalarial and Antitumor-Active Peroxides and Clarification of the Peroxide Relevance

Synthetic Approaches to Mono- and Bicyclic Perortho-Esters with a Central 1,2,4-Trioxane Ring as the Privileged Lead Structure in Antimalarial and Antitumor-Active Peroxides and Clarification of the Peroxide Relevance

The synthesis of 4-styryl-substituted 2,3,8-trioxabicyclo[3.3.1]nonanes, peroxides with the core structure of the bioactive 1,2,4-trioxane ring, was conducted by a multistep route starting from the aryl methyl ketones 1a–1c. Condensation and reduction/oxidation delivered enals 4a–4c that were couple...

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Bibliographic Details
Main Authors: Axel G. Griesbeck, Maria Bräutigam, Margarethe Kleczka, Angela Raabe
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
artemisinin
peroxides
singlet oxygen
hydroperoxides
1,2,4-trioxane
orthoester
Online Access:http://www.mdpi.com/1420-3049/22/1/119

Internet

http://www.mdpi.com/1420-3049/22/1/119

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