Predicting a double mutant in the twilight zone of low homology modeling for the skeletal muscle voltage-gated sodium channel subunit beta-1 (Nav1.4 β1)

Predicting a double mutant in the twilight zone of low homology modeling for the skeletal muscle voltage-gated sodium channel subunit beta-1 (Nav1.4 β1)

The molecular structure modeling of the β1 subunit of the skeletal muscle voltage-gated sodium channel (Nav1.4) was carried out in the twilight zone of very low homology. Structural significance can per se be confounded with random sequence similarities. Hence, we combined (i) not automated computat...

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Bibliographic Details
Main Authors: Thomas Scior, Bertin Paiz-Candia, Ángel A. Islas, Alfredo Sánchez-Solano, Lourdes Millan-Perez Peña, Claudia Mancilla-Simbro, Eduardo M. Salinas-Stefanon
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Ig-like
CDR1
MD-2
Patch-clamp
Site-directed mutagenesis
Analogy modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037015000148

Internet

http://www.sciencedirect.com/science/article/pii/S2001037015000148

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