Effects of diet-induced obesity and voluntary exercise in a tauopathy mouse model: Implications of persistent hyperleptinemia and enhanced astrocytic leptin receptor expression

The number of patients with Alzheimer's disease (AD) is increasing worldwide, and available drugs have shown limited efficacy. Hence, preventive interventions and treatments for presymptomatic AD are currently considered very important. Obesity rates have also been increasing dramatically and i...

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Bibliographic Details
Main Authors: Shunsuke Koga, Ayako Kojima, Chieko Ishikawa, Satoshi Kuwabara, Kimihito Arai, Yasumasa Yoshiyama
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Neurobiology of Disease
Subjects:
Tau
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002460