A1M/α1-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation.

A1M/α1-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation.

α1-microglobulin (A1M) is a 26 kDa plasma and tissue protein with reductase activity and radical- and heme-binding anti-oxidative functions. In addition, exposure of A1M to hemoglobin has been shown to induce proteolytic elimination of a C-terminal tetrapeptide yielding a heme-degrading form, trunca...

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Bibliographic Details
Main Authors: Martin eCederlund, Adnan eDeronic, Jan ePallon, Ole E Sørensen, Bo eÅkerström
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Physiology
Subjects:
Neutrophils
Myeloperoxidase
C-terminal proteolysis
Low density lipoprotein
Heme binding
α1-Microglobulin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00011/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00011/full

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