A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats

A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats

Abstract Background Metabolic syndrome (MetS) is a prevalent risk factor for cardiac dysfunction. Although SGLT2-inhibitors have important cardioprotective effects in hyperglycemia, their underlying mechanisms are complex and not completely understood. Therefore, we examined mechanisms of a SGLT2-in...

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Bibliographic Details
Main Authors: Aysegul Durak, Yusuf Olgar, Sinan Degirmenci, Erman Akkus, Erkan Tuncay, Belma Turan
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cardiovascular Diabetology
Subjects:
Diabetes
SGLT2 inhibitors
Heart function
Electrophysiology
Oxidative stress
Insulin resistance
Online Access:http://link.springer.com/article/10.1186/s12933-018-0790-0

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http://link.springer.com/article/10.1186/s12933-018-0790-0

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