Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei.

Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei.

Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle because the insect stage utilizes a cost-effective oxidative phosphorylation (OxPhos) to generate ATP, while bloodstream cells switch to aerobic glycolysis. Due to difficulties in acquiring enough parasit...

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Bibliographic Details
Main Authors: Eva Doleželová, Michaela Kunzová, Mario Dejung, Michal Levin, Brian Panicucci, Clément Regnault, Christian J Janzen, Michael P Barrett, Falk Butter, Alena Zíková
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000741

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https://doi.org/10.1371/journal.pbio.3000741

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