Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress

Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress

Macroautophagy (referred to as autophagy hereafter) plays an important role in the quality control of cellular proteins and organelles. Transcription Factor EB (TFEB) globally activates the expression of genes in the autophagic-lysosomal pathway (ALP) to replenish lysosomes and ALP machineries. We p...

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Bibliographic Details
Main Authors: Bo Pan, Megan T. Lewno, Penglong Wu, Xuejun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Physiology
Subjects:
macroautophagy
TFEB
mTOR
proteinopathy
proteotoxicity
mice
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00758/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00758/full

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