Controlling DNA-end resection: a new task for CDKs

DNA double-strand breaks (DSBs) are repaired by two major pathways: homologous recombination (HR) and nonhomologous end-joining (NHEJ). The choice between HR and NHEJ is highly regulated during the cell cycle. DNA-end resection, an evolutionarily conserved process that generates long stretches of si...

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Bibliographic Details
Main Authors: Lorenza P Ferretti, Lorenzo eLafranchi, Alessandro A Sartori
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Genetics
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00099/full