Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

We have identified a G-to-A transition in exon 3 of the APOC3 gene resulting in a novel Ala23Thr apolipoprotein (apo) C-III variant, associated with apoC-III deficiency in three unrelated Yucatan Indians. The Ala23Thr substitution modifies the hydrophobic/hydrophilic repartition of the helical N-ter...

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Bibliographic Details
Main Authors: Haiqun Liu, Christine Labeur, Chun-Fang Xu, Robert Ferrell, Laurence Lins, Robert Brasseur, Maryvonne Rosseneu, Kenneth M. Weiss, Steve E. Humphries, Philippa J. Talmud
Format: Article
Language:English
Published: Elsevier 2000-11-01
Series:Journal of Lipid Research
Subjects:
genetic variation
LPL inhibition
lipid binding
DMPC
apoE displacement
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520319696

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http://www.sciencedirect.com/science/article/pii/S0022227520319696

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