Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells

Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells

During mitosis, transcription is halted and many chromatin features are lost, posing a challenge for the continuity of cell identity, particularly in fast cycling stem cells, which constantly balance self-renewal with differentiation. Here we show that, in pluripotent stem cells, certain histone mar...

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Bibliographic Details
Main Authors: Yiyuan Liu, Bobbie Pelham-Webb, Dafne Campigli Di Giammartino, Jiexi Li, Daleum Kim, Katsuhiro Kita, Nestor Saiz, Vidur Garg, Ashley Doane, Paraskevi Giannakakou, Anna-Katerina Hadjantonakis, Olivier Elemento, Effie Apostolou
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
bookmarking
mitosis
cell identity
stemness
reprogramming
histone marks
transcription factors
Oct4
H3K27ac
ESCs
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471730596X

Internet

http://www.sciencedirect.com/science/article/pii/S221112471730596X

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