High expression of c-kit mRNA predicts unfavorable outcome in adult patients with t(8;21) acute myeloid leukemia.

High expression of c-kit mRNA predicts unfavorable outcome in adult patients with t(8;21) acute myeloid leukemia.

The reason that a certain subgroup of acute myeloid leukemia (AML) patients with t(8;21) translocation (generating the AML1/ETO fusion gene) displays a poor survival remains elusive. The proto-oncogene c-kit is expressed in approximately 80% of AML cases. The kinase domain mutation of the c-kit gene...

Full description

Bibliographic Details
Main Authors: Xiaoning Gao, Ji Lin, Li Gao, Ailing Deng, Xiaolin Lu, Yonghui Li, Lili Wang, Li Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4393018?pdf=render

Internet

http://europepmc.org/articles/PMC4393018?pdf=render

Similar Items