Role of Bruton’s tyrosine kinase in B cells and malignancies

Role of Bruton’s tyrosine kinase in B cells and malignancies

Abstract Bruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell malignancies. BTK was initially shown to be defective in the primary immunodeficiency X-linked agammaglob...

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Bibliographic Details
Main Authors: Simar Pal Singh, Floris Dammeijer, Rudi W. Hendriks
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
B cell development
B cell receptor signaling
Bruton’s tyrosine kinase
Chemokine receptor
Chronic lymphocytic leukemia
Ibrutinib
Online Access:http://link.springer.com/article/10.1186/s12943-018-0779-z

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http://link.springer.com/article/10.1186/s12943-018-0779-z

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