Quinuclidine-Based Carbamates as Potential CNS Active Compounds

Quinuclidine-Based Carbamates as Potential CNS Active Compounds

The treatment of central nervous system (CNS) diseases related to the decrease of neurotransmitter acetylcholine in neurons is based on compounds that prevent or disrupt the action of acetylcholinesterase and butyrylcholinesterase. A series of thirteen quinuclidine carbamates were designed using qui...

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Bibliographic Details
Main Authors: Ana Matošević, Andreja Radman Kastelic, Ana Mikelić, Antonio Zandona, Maja Katalinić, Ines Primožič, Anita Bosak, Tomica Hrenar
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
Alzheimer’s disease
acetylcholinesterase
butyrylcholinesterase
inhibition
covalent binding
cytotoxicity
Online Access:https://www.mdpi.com/1999-4923/13/3/420

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https://www.mdpi.com/1999-4923/13/3/420

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