Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

<h4>Background</h4>Amyloid-beta peptide species ending at positions 40 and 42 (Abeta40, Abeta42) are generated by the proteolytic processing of the Alzheimer's amyloid precursor protein (APP). Abeta peptides accumulate in the brain early in the course of Alzheimer's disease (AD...

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Main Authors: Yoshitake Sano, Tadashi Nakaya, Steve Pedrini, Shizu Takeda, Kanae Iijima-Ando, Koichi Iijima, Paul M Mathews, Shigeyoshi Itohara, Sam Gandy, Toshiharu Suzuki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-12-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0000051

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https://doi.org/10.1371/journal.pone.0000051

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