Antibody-free quantification of seven tau peptides in human CSF using targeted mass spectrometry

Antibody-free quantification of seven tau peptides in human CSF using targeted mass spectrometry

Tau protein concentration in cerebrospinal fluid (CSF) is currently used as a sensitive and specific biomarker for Alzheimer's disease. Its detection currently relies on ELISA but the perspective of using mass spectrometry (MS) to detect its different proteoforms represents an interesting alter...

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Bibliographic Details
Main Authors: Pauline eBros, Jérome eVialaret, Nicolas eBarthelemy, Vincent eDelatour, Audrey eGabelle, Sylvain eLehmann, Christophe eHirtz
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer Disease
LC-MS/MS
Quantitative Proteomics
tau protein
Human cerebrospinal fluid
Triple quadrupole LC/MS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00302/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00302/full

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