GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1

GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1

Background: Evidence supports that the hypofunction of N-methyl-D-aspartate receptor (NMDAR) and downregulation of disrupted-in-schizophrenia 1 (DISC1) contribute to the pathophysiology of schizophrenia. N-Methyl D-aspartate receptor subtype 2B (NR2B)-containing NMDAR are associated with cognitive d...

Full description

Bibliographic Details
Main Authors: Dongsheng Zhou, Dan Lv, Zhen Wang, Yanhua Zhang, Zhongming Chen, Chuang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
GLYX-13
disrupted-in-schizophrenia 1
N-methyl-D-aspartate receptor
N-methyl D-aspartate receptor subtype 2B
schizophrenia
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00121/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00121/full

Similar Items