The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease

The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease

Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in the amino-terminal region of the huntingtin protein (htt), leading to motor dysfunction, cognitive decline, psychiatric alterations, and death. The metabotropic glutamate recepto...

Full description

Bibliographic Details
Main Authors: J.G. Doria, J.M. de Souza, J.N. Andrade, H.A. Rodrigues, I.M. Guimaraes, T.G. Carvalho, C. Guatimosim, T. Dobransky, F.M. Ribeiro
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
CDPPB
Metabotropic glutamate receptors
Huntington's disease
BDNF
Neuroprotection
Memory and cognition
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002526

Internet

http://www.sciencedirect.com/science/article/pii/S0969996114002526

Similar Items