Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

INTRODUCTION: The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocor...

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Bibliographic Details
Main Authors: José L Santos, Rolando De la Cruz, Claus Holst, Katrine Grau, Carolina Naranjo, Alberto Maiz, Arne Astrup, Wim H M Saris, Ian MacDonald, Jean-Michel Oppert, Torben Hansen, Oluf Pedersen, Thorkild I A Sorensen, J Alfredo Martinez, NUGENOB Consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3114803?pdf=render

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http://europepmc.org/articles/PMC3114803?pdf=render

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