A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia [version 2; referees: 2 approved, 1 approved with reservations]

Background: Paclitaxel-induced peripheral neuropathy is a common and limiting side effect of an approved and effective chemotherapeutic agent. The cause of this nociception is still unknown. Methods: To uncover the mechanism involved in paclitaxel-induced pain, we developed a Drosophila thermal noci...

Full description

Bibliographic Details
Main Authors:	Zina Hamoudi, Thang Manh Khuong, Tiffany Cole, G. Gregory Neely
Format:	Article
Language:	English
Published:	F1000 Research Ltd 2018-10-01
Series:	F1000Research
Online Access:	https://f1000research.com/articles/7-99/v2

id	doaj-a2eb48380d3e466ab1c3585259313857
record_format	Article
spelling	doaj-a2eb48380d3e466ab1c35852593138572020-11-25T02:54:20ZengF1000 Research LtdF1000Research2046-14022018-10-01710.12688/f1000research.13581.218043A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia [version 2; referees: 2 approved, 1 approved with reservations]Zina Hamoudi0Thang Manh Khuong1Tiffany Cole2G. Gregory Neely3University of Sydney, Charles Perkins Centre and School of Life and Environmental Sciences, Camperdown, New South Wales, AustraliaUniversity of Sydney, Charles Perkins Centre and School of Life and Environmental Sciences, Camperdown, New South Wales, AustraliaUniversity of Sydney, Charles Perkins Centre and School of Life and Environmental Sciences, Camperdown, New South Wales, AustraliaUniversity of Sydney, Charles Perkins Centre and School of Life and Environmental Sciences, Camperdown, New South Wales, AustraliaBackground: Paclitaxel-induced peripheral neuropathy is a common and limiting side effect of an approved and effective chemotherapeutic agent. The cause of this nociception is still unknown. Methods: To uncover the mechanism involved in paclitaxel-induced pain, we developed a Drosophila thermal nociceptive model to show the effects of paclitaxel exposure on third instar larvae. Results: We found that paclitaxel increases heat nociception in a dose-dependent manner, and at the highest doses also obstructs dendritic repulsion cues. Conclusions: Our simple system can be applied to identify regulators of chemotherapy-induced pain and may help to eliminate pain-related side-effects of chemotherapy.https://f1000research.com/articles/7-99/v2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zina Hamoudi Thang Manh Khuong Tiffany Cole G. Gregory Neely
spellingShingle	Zina Hamoudi Thang Manh Khuong Tiffany Cole G. Gregory Neely A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia [version 2; referees: 2 approved, 1 approved with reservations] F1000Research
author_facet	Zina Hamoudi Thang Manh Khuong Tiffany Cole G. Gregory Neely
author_sort	Zina Hamoudi
title	A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia [version 2; referees: 2 approved, 1 approved with reservations]
title_short	A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia [version 2; referees: 2 approved, 1 approved with reservations]
title_full	A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia [version 2; referees: 2 approved, 1 approved with reservations]
title_fullStr	A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia [version 2; referees: 2 approved, 1 approved with reservations]
title_full_unstemmed	A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia [version 2; referees: 2 approved, 1 approved with reservations]
title_sort	fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia [version 2; referees: 2 approved, 1 approved with reservations]
publisher	F1000 Research Ltd
series	F1000Research
issn	2046-1402
publishDate	2018-10-01
description	Background: Paclitaxel-induced peripheral neuropathy is a common and limiting side effect of an approved and effective chemotherapeutic agent. The cause of this nociception is still unknown. Methods: To uncover the mechanism involved in paclitaxel-induced pain, we developed a Drosophila thermal nociceptive model to show the effects of paclitaxel exposure on third instar larvae. Results: We found that paclitaxel increases heat nociception in a dose-dependent manner, and at the highest doses also obstructs dendritic repulsion cues. Conclusions: Our simple system can be applied to identify regulators of chemotherapy-induced pain and may help to eliminate pain-related side-effects of chemotherapy.
url	https://f1000research.com/articles/7-99/v2
work_keys_str_mv	AT zinahamoudi afruitflymodelforstudyingpaclitaxelinducedperipheralneuropathyandhyperalgesiaversion2referees2approved1approvedwithreservations AT thangmanhkhuong afruitflymodelforstudyingpaclitaxelinducedperipheralneuropathyandhyperalgesiaversion2referees2approved1approvedwithreservations AT tiffanycole afruitflymodelforstudyingpaclitaxelinducedperipheralneuropathyandhyperalgesiaversion2referees2approved1approvedwithreservations AT ggregoryneely afruitflymodelforstudyingpaclitaxelinducedperipheralneuropathyandhyperalgesiaversion2referees2approved1approvedwithreservations AT zinahamoudi fruitflymodelforstudyingpaclitaxelinducedperipheralneuropathyandhyperalgesiaversion2referees2approved1approvedwithreservations AT thangmanhkhuong fruitflymodelforstudyingpaclitaxelinducedperipheralneuropathyandhyperalgesiaversion2referees2approved1approvedwithreservations AT tiffanycole fruitflymodelforstudyingpaclitaxelinducedperipheralneuropathyandhyperalgesiaversion2referees2approved1approvedwithreservations AT ggregoryneely fruitflymodelforstudyingpaclitaxelinducedperipheralneuropathyandhyperalgesiaversion2referees2approved1approvedwithreservations
_version_	1724721918401052672

A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia [version 2; referees: 2 approved, 1 approved with reservations]

Similar Items