Apoptotic lymphocytes of H. sapiens lose nucleosomes in GC-rich promoters.

We analyzed two sets of human CD4+ nucleosomal DNA directly sequenced by Illumina (Solexa) high throughput sequencing method. The first set has ∼40 M sequences and was produced from the normal CD4+ T lymphocytes by micrococcal nuclease. The second set has ∼44 M sequences and was obtained from periph...

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Bibliographic Details
Main Authors: Sergey Hosid, Ilya Ioshikhes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4117428?pdf=render