Valproic acid causes proteasomal degradation of DICER and influences miRNA expression.

Valproic acid causes proteasomal degradation of DICER and influences miRNA expression.

Valproic acid (VPA) is a commonly used drug to treat epilepsy and bipolar disorders. Known properties of VPA are inhibitions of histone deacetylases and activation of extracellular signal regulated kinases (ERK), which cannot fully explain VPA's clinical features. We found that VPA induces the...

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Bibliographic Details
Main Authors: Zhaiyi Zhang, Paolo Convertini, Manli Shen, Xiu Xu, Frédéric Lemoine, Pierre de la Grange, Douglas A Andres, Stefan Stamm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3866160?pdf=render

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http://europepmc.org/articles/PMC3866160?pdf=render

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