Success of Crizotinib Combined with Whole-Brain Radiotherapy for Brain Metastases in a Patient with Anaplastic Lymphoma Kinase Rearrangement-Positive Non-Small-Cell Lung Cancer

Success of Crizotinib Combined with Whole-Brain Radiotherapy for Brain Metastases in a Patient with Anaplastic Lymphoma Kinase Rearrangement-Positive Non-Small-Cell Lung Cancer

Although crizotinib shows marked antitumor activity in anaplastic lymphoma kinase (ALK) rearrangement-positive non-small-cell lung cancer (NSCLC) patients, all treated patients ultimately develop resistance to this drug. Isolated central nervous system failure without progression at extracranial sit...

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Bibliographic Details
Main Authors: Sachi Okawa, Takuo Shibayama, Atsushi Shimonishi, Jun Nishimura, Taichi Ozeki, Kenji Takada, Hiroe Kayatani, Daisuke Minami, Ken Sato, Keiichi Fujiwara, Toshiro Yonei, Toshio Sato, Manabu Suno
Format: Article
Language:English
Published: Karger Publishers 2018-11-01
Series:Case Reports in Oncology
Subjects:
ALK rearrangement-positive NSCLC
Leptomeningeal carcinomatosis
Central nervous system failure
Crizotinib
Whole-brain radiotherapy
Blood-brain barrier permeability
Online Access:https://www.karger.com/Article/FullText/492150

Internet

https://www.karger.com/Article/FullText/492150

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