Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice

Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice

Curing spinal cord injury (SCI) in mammals is a daunting task because of the lack of permissive mechanisms and strong inhibitory responses at and around the lesion. The neural cell adhesion molecule L1CAM (L1) has been shown to favor axonal regrowth and enhance neuronal survival and synaptic plastic...

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Bibliographic Details
Main Authors: Junping Xu, Chengliang Hu, Qiong Jiang, Hongchao Pan, Huifan Shen, Melitta Schachner
Format: Article
Language:English
Published: The Company of Biologists 2017-09-01
Series:Disease Models & Mechanisms
Subjects:
L1CAM mimetics
Small organic compounds
Trimebutine
Honokiol
Spinal cord injury
Mouse
Online Access:http://dmm.biologists.org/content/10/9/1117

Internet

http://dmm.biologists.org/content/10/9/1117

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