Trichosanthin-induced autophagy in gastric cancer cell MKN-45 is dependent on reactive oxygen species (ROS) and NF-κB/p53 pathway

Trichosanthin-induced autophagy in gastric cancer cell MKN-45 is dependent on reactive oxygen species (ROS) and NF-κB/p53 pathway

Trichosanthin (TCS), isolated from the root tuber of Trichosanthes kirilowii tubers in the Cucurbitaceae family, owns a great deal of biological and pharmacological activities including anti-virus and anti-tumor. TCS has been reported to induce cell apoptosis of a diversity of cancers, including cer...

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Bibliographic Details
Main Authors: Bin Wei, Qiaoying Huang, Shunrong Huang, Wei Mai, Xiaogang Zhong
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Journal of Pharmacological Sciences
Subjects:
Trichosanthin
Autophagy
Apoptosis
Gastric cancer
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316000360

Internet

http://www.sciencedirect.com/science/article/pii/S1347861316000360

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