B cell zone reticular cell microenvironments shape CXCL13 gradient formation

Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes forms both soluble and immobilized gradients to r...

Full description

Bibliographic Details
Main Authors:	Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17135-2

id	doaj-a29fe9ea7a8d465093c19a3301a148f3
record_format	Article
spelling	doaj-a29fe9ea7a8d465093c19a3301a148f32021-07-25T11:39:55ZengNature Publishing GroupNature Communications2041-17232020-07-0111111510.1038/s41467-020-17135-2B cell zone reticular cell microenvironments shape CXCL13 gradient formationJason Cosgrove0Mario Novkovic1Stefan Albrecht2Natalia B. Pikor3Zhaoukun Zhou4Lucas Onder5Urs Mörbe6Jovana Cupovic7Helen Miller8Kieran Alden9Anne Thuery10Peter O’Toole11Rita Pinter12Simon Jarrett13Emily Taylor14Daniel Venetz15Manfred Heller16Mariagrazia Uguccioni17Daniel F. Legler18Charles J. Lacey19Andrew Coatesworth20Wojciech G. Polak21Tom Cupedo22Bénedicte Manoury23Marcus Thelen24Jens V. Stein25Marlene Wolf26Mark C. Leake27Jon Timmis28Burkhard Ludewig29Mark C. Coles30York Computational Immunology Lab, University of YorkInstitute of Immunobiology, Kantonsspital St. GallenTheodor Kocher Institute, University of BernInstitute of Immunobiology, Kantonsspital St. GallenDepartment of Biology, University of YorkInstitute of Immunobiology, Kantonsspital St. GallenInstitute of Immunobiology, Kantonsspital St. GallenInstitute of Immunobiology, Kantonsspital St. GallenDepartment of Biology, University of YorkYork Computational Immunology Lab, University of YorkCentre for Immunology and Infection, Department of Biology and Hull York Medical School, University of YorkDepartment of Biology, University of YorkKennedy Institute of Rheumatology at the University of OxfordKennedy Institute of Rheumatology at the University of OxfordCentre for Immunology and Infection, Department of Biology and Hull York Medical School, University of YorkInstitute for Research in Biomedicine, Università della Svizzera italianaDepartment of Clinical Research, University of BernInstitute for Research in Biomedicine, Università della Svizzera italianaBiotechnology Institute Thurgau (BITg) at the University of KonstanzYork Computational Immunology Lab, University of YorkYork Teaching Hospital NHS Foundation TrustDepartment of Surgery, Erasmus University Medical CentreDepartment of Hematology, Erasmus University Medical CentreInstitut Necker Enfants Malades, INSERM U1151- CNRS UMR 8253, 149 rue de Sèvres 75015 Paris, France Université René DescartesInstitute for Research in Biomedicine, Università della Svizzera italianaDepartment of Oncology, Microbiology and Immunology, University of FribourgTheodor Kocher Institute, University of BernDepartment of Biology, University of YorkYork Computational Immunology Lab, University of YorkInstitute of Immunobiology, Kantonsspital St. GallenYork Computational Immunology Lab, University of YorkMorphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes forms both soluble and immobilized gradients to regulate B cell recruitment and migration.https://doi.org/10.1038/s41467-020-17135-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jason Cosgrove Mario Novkovic Stefan Albrecht Natalia B. Pikor Zhaoukun Zhou Lucas Onder Urs Mörbe Jovana Cupovic Helen Miller Kieran Alden Anne Thuery Peter O’Toole Rita Pinter Simon Jarrett Emily Taylor Daniel Venetz Manfred Heller Mariagrazia Uguccioni Daniel F. Legler Charles J. Lacey Andrew Coatesworth Wojciech G. Polak Tom Cupedo Bénedicte Manoury Marcus Thelen Jens V. Stein Marlene Wolf Mark C. Leake Jon Timmis Burkhard Ludewig Mark C. Coles
spellingShingle	Jason Cosgrove Mario Novkovic Stefan Albrecht Natalia B. Pikor Zhaoukun Zhou Lucas Onder Urs Mörbe Jovana Cupovic Helen Miller Kieran Alden Anne Thuery Peter O’Toole Rita Pinter Simon Jarrett Emily Taylor Daniel Venetz Manfred Heller Mariagrazia Uguccioni Daniel F. Legler Charles J. Lacey Andrew Coatesworth Wojciech G. Polak Tom Cupedo Bénedicte Manoury Marcus Thelen Jens V. Stein Marlene Wolf Mark C. Leake Jon Timmis Burkhard Ludewig Mark C. Coles B cell zone reticular cell microenvironments shape CXCL13 gradient formation Nature Communications
author_facet	Jason Cosgrove Mario Novkovic Stefan Albrecht Natalia B. Pikor Zhaoukun Zhou Lucas Onder Urs Mörbe Jovana Cupovic Helen Miller Kieran Alden Anne Thuery Peter O’Toole Rita Pinter Simon Jarrett Emily Taylor Daniel Venetz Manfred Heller Mariagrazia Uguccioni Daniel F. Legler Charles J. Lacey Andrew Coatesworth Wojciech G. Polak Tom Cupedo Bénedicte Manoury Marcus Thelen Jens V. Stein Marlene Wolf Mark C. Leake Jon Timmis Burkhard Ludewig Mark C. Coles
author_sort	Jason Cosgrove
title	B cell zone reticular cell microenvironments shape CXCL13 gradient formation
title_short	B cell zone reticular cell microenvironments shape CXCL13 gradient formation
title_full	B cell zone reticular cell microenvironments shape CXCL13 gradient formation
title_fullStr	B cell zone reticular cell microenvironments shape CXCL13 gradient formation
title_full_unstemmed	B cell zone reticular cell microenvironments shape CXCL13 gradient formation
title_sort	b cell zone reticular cell microenvironments shape cxcl13 gradient formation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes forms both soluble and immobilized gradients to regulate B cell recruitment and migration.
url	https://doi.org/10.1038/s41467-020-17135-2
work_keys_str_mv	AT jasoncosgrove bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT marionovkovic bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT stefanalbrecht bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT nataliabpikor bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT zhaoukunzhou bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT lucasonder bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT ursmorbe bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT jovanacupovic bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT helenmiller bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT kieranalden bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT annethuery bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT peterotoole bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT ritapinter bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT simonjarrett bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT emilytaylor bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT danielvenetz bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT manfredheller bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT mariagraziauguccioni bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT danielflegler bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT charlesjlacey bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT andrewcoatesworth bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT wojciechgpolak bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT tomcupedo bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT benedictemanoury bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT marcusthelen bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT jensvstein bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT marlenewolf bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT markcleake bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT jontimmis bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT burkhardludewig bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation AT markccoles bcellzonereticularcellmicroenvironmentsshapecxcl13gradientformation
_version_	1721282887038271488

B cell zone reticular cell microenvironments shape CXCL13 gradient formation

Similar Items